HCMV Vaccine Development Targets Immunomodulatory Proteins

Guest Commentary by Anamaris Colberg-Poley* Human cytomegalovirus (HCMV) can cause severe disease in immunocompromised individuals and in congenitally infected infants, thus the development of an HCMV vaccine has been a national priority over the last few decades.  Despite attempts similar to those which have proven successful for other herpesviruses, such as varicella zoster virus, attenuated HCMV […]

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New and Notable This Week

This week’s selection of recently published papers from MDPI journals.

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Towards Therapeutic Use of Antimicrobial Peptides: Conferring Cell Selectivity by Introducing Specificity Determinants

Guest Commentary by Guangshun Wang* We are living in an era of antibiotic resistance; fortunately, there is widespread recognition of the consequences of this dilemma. While scientists have long been fascinated by the impressive diversity of antimicrobial peptides (also called host defense peptides) that exist in bacteria, protozoa, fungi, plants, and animals, there is a […]

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Non-coding RNAs: Regulatory Guardians of the Genome

Guest Post by Franck Vazquez* During the last two decades the Central Dogma of Biology, which states that genetic information flows from DNA into messenger RNAs (mRNAs) via transcription, and from mRNAs into functional proteins via translation, has been shown to be far more complicated than what had long been accepted. Indeed, cells transcribe thousands of RNAs, which neither […]

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Monoclonal Antibody to HCMV Glycoprotein B Blocks Viral Entry and Growth in Trophoblast Progenitor Cells

Guest Commentary by Anamaris Colberg-Poley* Human cytomegalovirus (HCMV) is the major cause of congenital birth infections in developed countries.  HCMV can cause severe birth defects including microcephaly, mental retardation, sensorineural hearing loss, and intrauterine growth restriction. However, because of the potential for teratogenicity and toxic effects, no therapeutic treatment is currently approved by the Food […]

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Controlling Sugar Intake: A Platform to Predict Glycosylation for Therapeutic Antibodies

Glycoproteins are formed through protein glycosylation, the post-translational addition and processing of covalently bound oligosaccharide chains. Variations in the glycoform of proteins result from multiple factors in this process, such as enzyme and substrate availability, and these differences can influence the stability and biological function of the protein1.

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Flotillins: Signals from a Raft

Flotillins are highly homologous proteins (known as flotillin-1 and flotillin-2, or reggie-2 and reggie-1, respectively) that localize to membrane rafts (specific cholesterol-rich microdomains in cellular membranes), and are associated with various signaling pathways, cell adhesion, membrane trafficking and axonal growth.

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Leon Terstappen on Circulating Tumor Cells: Biology and Technology

Tumor metastases cause ninety percent of cancer deaths, and occur when cells detach from a primary tumor and form new malignancies elsewhere. This process involves circulating tumor cells (CTC) which intravasate and extravasate (enter and exit the blood vessels) allowing migration to other parts of the body.

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Evolution and Diversification of Snake Venom Toxins

Snake venom toxins are well-known for their profound physiological effects that enable their use as tools to aid basic research and clarify pathological processes; they also have enormous potential in drug design and development. Further, an area of growing interest is the molecular evolution and diversification of these toxins, a particularly rapid and dynamic process for which the underlying mechanisms […]

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Gluten Sensitive?

Non-celiac gluten sensitivity (NCGS) is defined as intestinal and non-intestinal symptoms resulting from the ingestion of gluten, and which is not due to celiac disease (CD) or wheat allergy. Gluten sensitivity appears to be increasing and is thus a topic of significant public and research interest;  a recent paper published in the journal Nutrients describes progress in the […]

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