RNA Biology and Plasticity—Interview with Dr. John Mattick

The human genome contains only about 20,000 protein-coding genes, however the extent of non-protein-coding DNA increases with increasing developmental and cognitive complexity. These sequences are transcribed to produce small and large non-protein-coding RNAs that guide chromatin-modifying complexes to their sites of action and thereby modulate chromatin structure and gene expression, to specify the architectural trajectories […]

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