Flavonoid Thiol Toxicity: What’s in a Group?
Antioxidants are a direct consequence of the highly oxidizing environment (21% atmospheric dioxygen) in which we live on the third rock from the sun. The switch from anaerobic to aerobic metabolism during the evolution of the majority of organisms on this planet not only resulted in a more efficient liberation of energy from glucose (~30 […]More Info
The Proteasome Activator PA28γ and P53: It Takes Two to Tango, but Which One Takes the Lead?
The phosphoprotein p53 was trivially named after the apparent molecular mass it runs on SDS-PAGE, i.e., 53-kilodalton (kDa). Ever since its discovery in 1979 by several groups simultaneously, this extraordinary protein has captured the imagination of life scientists. p53 is likely the most extensively studied protein in cell biological research. To underscore its importance, p53 […]More Info
Non-coding RNAs: Regulatory Guardians of the Genome
Guest Post by Franck Vazquez* During the last two decades the Central Dogma of Biology, which states that genetic information flows from DNA into messenger RNAs (mRNAs) via transcription, and from mRNAs into functional proteins via translation, has been shown to be far more complicated than what had long been accepted. Indeed, cells transcribe thousands of RNAs, which neither […]More Info