RNA Biology and Plasticity—Interview with Dr. John Mattick

The human genome contains only about 20,000 protein-coding genes, however the extent of non-protein-coding DNA increases with increasing developmental and cognitive complexity. These sequences are transcribed to produce small and large non-protein-coding RNAs that guide chromatin-modifying complexes to their sites of action and thereby modulate chromatin structure and gene expression, to specify the architectural trajectories […]

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Non-Coding RNAs and Epigenetics in Cancer: An interview with Dr. Carlo Croce

One of the most unexpected and fascinating discoveries in oncology over the past decade has been the interplay between abnormalities in protein-coding genes and non-coding RNAs (ncRNAs), which are causally involved in cancer initiation, progression, and dissemination. Although, to date, the most studied non-coding RNAs (ncRNAs) are microRNAs (miRNAs), the importance of long non-coding RNAs […]

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