Leon Terstappen on Circulating Tumor Cells: Biology and Technology

Tumor metastases cause ninety percent of cancer deaths, and occur when cells detach from a primary tumor and form new malignancies elsewhere. This process involves circulating tumor cells (CTC) which intravasate and extravasate (enter and exit the blood vessels) allowing migration to other parts of the body.

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Evolution and Diversification of Snake Venom Toxins

Snake venom toxins are well-known for their profound physiological effects that enable their use as tools to aid basic research and clarify pathological processes; they also have enormous potential in drug design and development. Further, an area of growing interest is the molecular evolution and diversification of these toxins, a particularly rapid and dynamic process for which the underlying mechanisms […]

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Gluten Sensitive?

Non-celiac gluten sensitivity (NCGS) is defined as intestinal and non-intestinal symptoms resulting from the ingestion of gluten, and which is not due to celiac disease (CD) or wheat allergy. Gluten sensitivity appears to be increasing and is thus a topic of significant public and research interest;  a recent paper published in the journal Nutrients describes progress in the […]

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Paul Tchounwou to Receive the 2013 AAAS Mentor Award

The American Association for the Advancement of Science (AAAS) Board has chosen Paul Tchounwou, Editor-in-Chief of the International Journal of Environmental Research and Public Health (IJERPH), to receive the 2013 AAAS Mentor Award. This award honors extraordinary leadership to increase the participation of underrepresented groups in science and engineering fields and will be presented at the AAAS annual meeting […]

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Tumor-Directed Radiotherapy Upregulates the Immune Response

In the current issue of Diagnostics, Wu, Pfeifer and colleagues demonstrate how targeted radionuclide anti-tumor therapy upregulates specific cells of the immune system, advancing understanding of the host immune response to treatment and facilitating the optimization of dosage and protocols for improved patient outcomes.

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Arthropod Appreciation Day

Soil arthropods, invertebrate animals with exoskeletons, including ants, termites and millipedes, munch their way through plant litter that ends up as the nutrient rich soil upon which complex terrestrial life depends. Most of us, though, are likely only dimly aware of the essential roles arthropods play in maintaining ecosystems. We are more apt to regard […]

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Good News for BAD (Bile Acid Diarrhoea)

Bile acid diarrhoea (BAD) is a common cause of chronic diarrhoea and can be highly debilitating, causing a significant reduction in the quality of life. It is unfortunately under-recognized and under-diagnosed by clinicians as the cause for this common affliction. This is mostly due to current definitive testing requiring expensive and advanced nuclear medicine technology […]

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Stroke Protection: a Thrombin Inhibitor Steps Forward

A stroke is the result of loss of adequate blood supply to the brain and is a major cause of disability worldwide, and the second leading cause of death after 60 years of age. Each year roughly 15 million people suffer a stroke and 6 million die from it. Ischemic stroke (versus hemorrhagic) accounts for […]

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A Code by Any Other Name

Advances in next generation sequencing technologies, particularly RNA-seq, have revealed an unexpectedly large extent of human genome transcription, estimated between 60-90%, and propelled the rapidly growing field of transcriptomics. Since protein-coding genes account for less than 3% of the human genome (numbering about 20,000, or half that of Oryza sativa (rice), and about the same […]

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Toxic Relationships with Heavy Metals

Chlorinated organic solvents, manufactured in large quantities and widely used in industry for degreasing fats and resins, are among the most prevalent organic pollutants that contaminate groundwater and subsurface soils. Spills and leakages of these compounds in areas with heavy metal contamination have caused difficult to eradicate toxic sites since heavy metals can interfere with […]

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