New and Notable This Week

This week’s selection of recently published papers from MDPI journals.

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Non-coding RNAs: Regulatory Guardians of the Genome

Guest Post by Franck Vazquez* During the last two decades the Central Dogma of Biology, which states that genetic information flows from DNA into messenger RNAs (mRNAs) via transcription, and from mRNAs into functional proteins via translation, has been shown to be far more complicated than what had long been accepted. Indeed, cells transcribe thousands of RNAs, which neither […]

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Controlling Sugar Intake: A Platform to Predict Glycosylation for Therapeutic Antibodies

Glycoproteins are formed through protein glycosylation, the post-translational addition and processing of covalently bound oligosaccharide chains. Variations in the glycoform of proteins result from multiple factors in this process, such as enzyme and substrate availability, and these differences can influence the stability and biological function of the protein1.

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Stroke Protection: a Thrombin Inhibitor Steps Forward

A stroke is the result of loss of adequate blood supply to the brain and is a major cause of disability worldwide, and the second leading cause of death after 60 years of age. Each year roughly 15 million people suffer a stroke and 6 million die from it. Ischemic stroke (versus hemorrhagic) accounts for […]

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A Code by Any Other Name

Advances in next generation sequencing technologies, particularly RNA-seq, have revealed an unexpectedly large extent of human genome transcription, estimated between 60-90%, and propelled the rapidly growing field of transcriptomics. Since protein-coding genes account for less than 3% of the human genome (numbering about 20,000, or half that of Oryza sativa (rice), and about the same […]

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Toxic Relationships with Heavy Metals

Chlorinated organic solvents, manufactured in large quantities and widely used in industry for degreasing fats and resins, are among the most prevalent organic pollutants that contaminate groundwater and subsurface soils. Spills and leakages of these compounds in areas with heavy metal contamination have caused difficult to eradicate toxic sites since heavy metals can interfere with […]

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