Finding the Best Fit: Bayesian Statistics Meets Geometry

A common problem faced in research is when a set of data has been collected on the one hand, and a theoretical model (a set of equations with input parameters) exists on the other. We want to know firstly, whether the model describes the data well and secondly, what variables of the model give the […]

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In Silico Docking of Bolinaquinone at Clathrin Terminal Domain

Guest Commentary by Derek McPhee Endocytosis is a fundamental process that delivers macromolecules located outside the cell or on the cell membrane to the cytoplasm. It is a necessary process for nutrients to reach the cell, and for regulation of numerous transmembrane receptors. Of the various ways whereby cargo can access the cytoplasm, one of […]

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HCMV Vaccine Development Targets Immunomodulatory Proteins

Guest Commentary by Anamaris Colberg-Poley* Human cytomegalovirus (HCMV) can cause severe disease in immunocompromised individuals and in congenitally infected infants, thus the development of an HCMV vaccine has been a national priority over the last few decades.  Despite attempts similar to those which have proven successful for other herpesviruses, such as varicella zoster virus, attenuated HCMV […]

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Towards Therapeutic Use of Antimicrobial Peptides: Conferring Cell Selectivity by Introducing Specificity Determinants

Guest Commentary by Guangshun Wang* We are living in an era of antibiotic resistance; fortunately, there is widespread recognition of the consequences of this dilemma. While scientists have long been fascinated by the impressive diversity of antimicrobial peptides (also called host defense peptides) that exist in bacteria, protozoa, fungi, plants, and animals, there is a […]

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Monoclonal Antibody to HCMV Glycoprotein B Blocks Viral Entry and Growth in Trophoblast Progenitor Cells

Guest Commentary by Anamaris Colberg-Poley* Human cytomegalovirus (HCMV) is the major cause of congenital birth infections in developed countries.  HCMV can cause severe birth defects including microcephaly, mental retardation, sensorineural hearing loss, and intrauterine growth restriction. However, because of the potential for teratogenicity and toxic effects, no therapeutic treatment is currently approved by the Food […]

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