Kudos to our Peer-Reviewers and Journal Rejection Rates in 2013

Kudos to our Peer-Reviewers and Journal Rejection Rates in 2013

Our journals received nearly 20’000 manuscript submissions in 2013, or about 75 submissions per business day. It is a logistical challenge to handle this number of incoming manuscripts, to screen them appropriately, expedite them to external peer-review and to communicate with authors to keep them informed and advise them on revisions. More than 100 in-house editors are employed by MDPI to handle the manuscripts through peer-review, to manage the correspondence with referees and authors, and to guide accepted manuscripts through copy-editing, English editing and production. However, the most valuable part of the work is done by external academic editors and referees that generously donate their time to ensure that our journals publish high quality work. Continue reading

Monoclonal Antibody to HCMV Glycoprotein B Blocks Viral Entry and Growth in Trophoblast Progenitor Cells

Guest Commentary by Anamaris Colberg-Poley*

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Human cytomegalovirus (HCMV) is the major cause of congenital birth infections in developed countries.  HCMV can cause severe birth defects including microcephaly, mental retardation, sensorineural hearing loss, and intrauterine growth restriction. However, because of the potential for teratogenicity and toxic effects, no therapeutic treatment is currently approved by the Food and Drug Administration for congenital HCMV infection. The studies by Lenore Pereira and her colleagues (Zydek et al., 2014.  Viruses  Special Issue on Recent CMV Research) have significant implications for developing therapies for treatment of congenital HCMV infections, which are seriously lacking at this time. Continue reading

Controlling Sugar Intake: A Platform to Predict Glycosylation for Therapeutic Antibodies

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Glycoproteins are formed through protein glycosylation, the post-translational addition and processing of covalently bound oligosaccharide chains. Variations in the glycoform of proteins result from multiple factors in this process, such as enzyme and substrate availability, and these differences can influence the stability and biological function of the protein1. Continue reading

Open Access Publishing – Transparency and Accountability in Scientific Research and Publishing

Open Access Publishing – Transparency and Accountability in Scientific Research and Publishing

Scientific publishing, and communication in general, has changed rapidly and radically over the past 20 years. With the advent of the Internet, communication and publishing has become affordable to all, to the point that one only needs a few megabytes of online space, a HTML editor and a word processor to claim to be a “Publisher”. (Actually, even a WordPress.com account would suffice to this purpose. Registering and configuring this blog using WordPress.com took me about two hours. I can now publish this first post on the blog.). There is no doubt that a number of dubious operations from across the globe are popping and claiming to be academic publishers. Continue reading